Invention Grant
- Patent Title: Process and composition for stabilization of vulnerable plaque utilizing a combination of a statin and omega 3 fatty acids
- Patent Title (中): 利用他汀类和ω-3脂肪酸的组合来稳定易损斑块的方法和组合物
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Application No.: US14594095Application Date: 2015-01-10
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Publication No.: US09248138B2Publication Date: 2016-02-02
- Inventor: George Jackowski , Rachelle MacSweeney , Nisar Ahmad Shaikh , Jason Yantha , Valerie B. Schini-Kerth
- Applicant: PIVOTAL THERAPEUTICS INC.
- Applicant Address: CA Ontario
- Assignee: Pivotal Therapeutics, Inc.
- Current Assignee: Pivotal Therapeutics, Inc.
- Current Assignee Address: CA Ontario
- Agency: Ferris H. Lander, Inc.
- Main IPC: A61K31/662
- IPC: A61K31/662 ; A61K31/505 ; A61K31/4418 ; A61K31/47 ; A61K31/40 ; A61K31/404 ; A61K31/366 ; A61K31/22 ; A61K31/232
Abstract:
A composition and a method of treatment utilizing a combination of statins (or HMG-CoA reductase inhibitors), a class of drug used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, with mixtures of an omega-3 fatty acid formulation containing about 90% or more omega 3 fatty acids by weight including a combination of Eicosapentaenoic acid (EPA), Docosapentaenoic acid (DPA) and Docosahexaenoic acid (DHA) in a weight ratio of EPA:DHA of from 5.7 to 6.3, wherein the sum of the EPA, DHA and DPA represent about 82% by weight of the total formulation and about 92% of the total omega 3 fatty acid content of the composition, the compositions and method designed to stabilize vulnerable plaque while mediating omega-3 deficiencies in individuals in need thereof.
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