Invention Grant
US09248198B2 Peptide compositions and methods for treating lung injury, asthma, anaphylaxis, angioedema, systemic vascular permeability syndromes, and nasal congestion
有权
用于治疗肺损伤，哮喘，过敏反应，血管性水肿，全身血管通透性综合征和鼻充血的肽组合物和方法
- Patent Title: Peptide compositions and methods for treating lung injury, asthma, anaphylaxis, angioedema, systemic vascular permeability syndromes, and nasal congestion
- Patent Title (中): 用于治疗肺损伤，哮喘，过敏反应，血管性水肿，全身血管通透性综合征和鼻充血的肽组合物和方法
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Application No.: US14105385Application Date: 2012-06-13
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Publication No.: US09248198B2Publication Date: 2016-02-02
- Inventor: Yulia A. Komarova , Uzma Saqib , Stephen M. Vogel , Asrar B. Malik
- Applicant: Yulia A. Komarova , Uzma Saqib , Stephen M. Vogel , Asrar B. Malik
- Applicant Address: US IL Urbana
- Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Current Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Current Assignee Address: US IL Urbana
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/US2012/042118 WO 20120613
- International Announcement: WO2012/174028 WO 20121220
- Main IPC: C07K7/06
- IPC: C07K7/06 ; C07K14/705 ; A61K47/48 ; A61K38/00 ; A61K38/17 ; C07K7/08
Abstract:
Provided herein are peptide inhibitors of the interaction between End Binding Protein 3 (EB3) and Inositol 1,4,5-Trisphosphate Receptor Type 3 (IP3R3). Also provided are methods and materials for treating lung injury, including acute lung injury, which may include hyperpermeability of lung vessels, vascular leakage, the development of edema, asthma, anaphylaxis, angioedema, systemic vascular permeability syndromes, and nasal congestion.
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