Various embodiments of a secretion collection and/or sample analysis device are provided for point-of-care collection and/or analysis of secretions collected from the airways of intubated patients. The disclosed embodiments include a variety of placements of the device with respect to a tracheal tube that include in a secretion reservoir, between an evacuation conduit and the secretion reservoir, and connected in series after the evacuation conduit and the secretion reservoir. Certain embodiments may include a lab-on-a-chip device that analyzes secretions via polymerase chain reaction (PCR) based DNA sequencing.