A laser machine (1), in particular for drilling, cutting, welding or engraving, comprising at least one laser light source (3,4,5) for generating a laser beam (9) and an optical system (6) to guide and/or manipulate the laser beam (9), whereby the optical system (6) comprises at least one tool (23), in particular an optical lens (24) or a nozzle, which is attached to an interchangeable tool holder (12). It is provided that a guiding system (16) for the tool holder (12) is configured such that the tool holder (12) can only be slid sideways into or out of a tool bay (10) provided by the laser machine (1), the guiding system (16) comprising an operable locking system (37) for restraining the movement of the tool holder (12) in the tool bay (10).