Invention Grant
US09249084B2 Substituted n-pentanamide compounds, preparation method and the use thereof
有权
取代的正戊酰胺化合物，其制备方法及其用途
- Patent Title: Substituted n-pentanamide compounds, preparation method and the use thereof
- Patent Title (中): 取代的正戊酰胺化合物，其制备方法及其用途
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Application No.: US13982733Application Date: 2012-01-31
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Publication No.: US09249084B2Publication Date: 2016-02-02
- Inventor: Qiang Zhang , Rongxia Zhang , Guanghui Tian , Jianfeng Li , Fuqiang Zhu , Xiangrui Jiang , Jingshan Shen
- Applicant: Qiang Zhang , Rongxia Zhang , Guanghui Tian , Jianfeng Li , Fuqiang Zhu , Xiangrui Jiang , Jingshan Shen
- Applicant Address: CN Shanghai CN Shanghai
- Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Topharman Shanghai Co., Ltd.
- Current Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Topharman Shanghai Co., Ltd.
- Current Assignee Address: CN Shanghai CN Shanghai
- Agency: Andrews Kurth LLP
- Agent Ping Wang
- Priority: CN201110034202 20110131
- International Application: PCT/CN2012/070781 WO 20120131
- International Announcement: WO2012/103799 WO 20120809
- Main IPC: C07C213/02
- IPC: C07C213/02 ; C07C59/64 ; C07C235/34 ; C07C309/75 ; C07C309/66 ; C07C43/225 ; C07D263/26 ; C07C17/16 ; C07C215/54 ; C07C217/62 ; C07C309/73 ; C07D263/52 ; C07C43/23 ; C07C59/68 ; C07C41/26
Abstract:
The present invention relates to a (2R,3R)-3-(3-substituted phenyl)-2-methyl n-pentanamide compounds as shown in the formula I and the preparation method thereof, wherein, the substituents are as defined in the specification, the present invention further relates to a use of the above compounds for the preparation of tapentadol II or its pharmaceutically acceptable salt, and the intermediates involved in the preparation process.
Public/Granted literature
- US20140046074A1 Substituted n-pentanamide compounds, preparation method and the use thereof Public/Granted day:2014-02-13
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