Invention Grant
- Patent Title: Aniline derivatives, their preparation and their therapeutic application
- Patent Title (中): 苯胺衍生物，其制备及其治疗应用
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Application No.: US14344925Application Date: 2012-09-07
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Publication No.: US09249085B2Publication Date: 2016-02-02
- Inventor: John Feutrill , Caroline Leriche , David Middlemiss
- Applicant: John Feutrill , Caroline Leriche , David Middlemiss
- Applicant Address: FR Paris
- Assignee: FOVEA PHARMACEUTICALS
- Current Assignee: FOVEA PHARMACEUTICALS
- Current Assignee Address: FR Paris
- Agency: Morrison & Foerster LLP
- Priority: EP11306170 20110916; EP12305130 20120203; EP12305626 20120604
- International Application: PCT/EP2012/067473 WO 20120907
- International Announcement: WO2013/037705 WO 20130321
- Main IPC: C07C217/84
- IPC: C07C217/84 ; C07C235/56 ; C07C233/75 ; C07C255/59 ; C07C63/72 ; C07C13/02 ; C07C13/08 ; C07C235/20 ; C07C237/30 ; A61K31/196 ; A61K45/06 ; A61K31/216 ; C07C215/76 ; C07C65/105 ; C07C65/24 ; A61K31/165 ; A61K31/277 ; A61K31/5375 ; C07C213/02 ; C07C213/08 ; C07C253/30 ; C07C255/57 ; C07C255/58 ; C07D295/088
Abstract:
The present invention relates to aniline derivatives of formula (I), to their preparation and to their therapeutic application, for example in treating glaucoma: Formula (I), R1a represents H, an halogen, a (C1-C6)alkyl or a CN; R1b represents H, an halogen or a (C1-C6)alkyl; R1c represents H or a (C1-C6)alkyl; R2 represents H, an halogen, an OH, an O—(C1-C6)alkyl or (C1-C6)alkyl; R3 represents H, an halogen, a (C1-C6)alkyl, an OH, an O—(C1-C6)alkyl, a CONH2 or CN; R4 represents H, an halogen or a (C1-C6)alkyl; R5 represents H or F: R7 represents H or F; R8 represents H or F; R9 represents H or (C1-C6)alkyl, or one of its enantiomers.
Public/Granted literature
- US20140350019A1 ANILINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION Public/Granted day:2014-11-27
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