Invention Grant
- Patent Title: Multicomponent system of rosuvastatin calcium salt and sorbitol
- Patent Title (中): 罗苏伐他汀钙盐和山梨醇的多组分体系
-
Application No.: US13574005Application Date: 2011-11-21
-
Publication No.: US09249108B2Publication Date: 2016-02-02
- Inventor: Andreas Hafner , Fritz Blatter , Martin Szelagiewicz , Bernd Siebenhaar
- Applicant: Andreas Hafner , Fritz Blatter , Martin Szelagiewicz , Bernd Siebenhaar
- Applicant Address: DE Ludwigshafen
- Assignee: BASF SE
- Current Assignee: BASF SE
- Current Assignee Address: DE Ludwigshafen
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P
- Priority: EP10192045 20101122
- International Application: PCT/EP2011/070520 WO 20111121
- International Announcement: WO2012/069394 WO 20120531
- Main IPC: C07D239/42
- IPC: C07D239/42 ; C07C29/00 ; C07C31/26 ; A61K31/505 ; A61K47/26 ; A61K47/48
Abstract:
A novel solid form of Rosuvastatin comprises as the active ingredient a salt of bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid] and sorbitol. The crystal comprising the two components, and minor amounts of water, shows improved properties such as crystallization behavior and stability.
Public/Granted literature
- US20130237553A1 MULTICOMPONENT SYSTEM OF RESUVASTATIN CALCIUM SALT AND SORBITOL Public/Granted day:2013-09-12
Information query
