Invention Grant
- Patent Title: Pyrazole derivatives as p38 MAP inhibitors
- Patent Title (中): 吡唑衍生物作为p38 MAP抑制剂
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Application No.: US14424361Application Date: 2013-08-28
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Publication No.: US09249125B2Publication Date: 2016-02-02
- Inventor: Lorna Anne Duffy , John King-Underwood , Alistair Ian Longshaw , Peter John Murray , Stuart Thomas Onions , David Michael Adrien Taddei , Jonathan Gareth Williams , Kazuhiro Ito , Catherine Elisabeth Charron
- Applicant: RESPIVERT LIMITED , TOPIVERT PHARMA LIMITED
- Applicant Address: GB Buckinghamshire GB London
- Assignee: RESPIVERT LIMITED,TOPIVERT PHARMA LIMITED
- Current Assignee: RESPIVERT LIMITED,TOPIVERT PHARMA LIMITED
- Current Assignee Address: GB Buckinghamshire GB London
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Priority: GB1215357.3 20120829
- International Application: PCT/GB2013/052252 WO 20130828
- International Announcement: WO2014/033448 WO 20140306
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D403/14 ; C07D405/14 ; C07D409/14 ; C07D413/14 ; C07D417/14 ; C07D471/04 ; A61K31/5377 ; A61K31/506

Abstract:
Compounds of formula (I): wherein R1, R2, J, Q, V, X, Y and Z are defined herein are disclosed. The compounds are inhibitors of the family of p38 mitogen-activated protein kinase enzymes (referred to herein as p38 MAP kinase inhibitors), particularly the alpha sub-type thereof, and of Syk kinase and the Src family of tyrosine kinases. The compounds may be used in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, in particular inflammatory diseases of the lung, such as asthma and COPD, as well as those of the gastrointestinal tract, such as ulcerative colitis and Crohn's disease and of the eye, such as uveitis.
Public/Granted literature
- US20150203475A1 PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS Public/Granted day:2015-07-23
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