Invention Grant
US09249144B2 Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
有权
用于合成8 - [{1-（3,5-双 - （三氟甲基）苯基） - 乙氧基} - 甲基] -8-苯基-1,7-二氮杂 - 螺[4.5]癸-2-醇的方法和中间体 一种化合物
![Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds](/docs/US/2016-02-02/US09249144B2/abs.jpg.600x600.jpg)
- Patent Title: Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
- Patent Title (中): 用于合成8 - [{1-（3,5-双 - （三氟甲基）苯基） - 乙氧基} - 甲基] -8-苯基-1,7-二氮杂 - 螺[4.5]癸-2-醇的方法和中间体 一种化合物
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Application No.: US14043210Application Date: 2013-10-01
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Publication No.: US09249144B2Publication Date: 2016-02-02
- Inventor: George G. Wu , Gerald Werne , Xiaoyong Fu , Robert K. Orr , Frank Xing Chen , Jian Cui , Victoria M. Sprague , Fucheng Zhang , Ji Xie , Liansheng Zeng , Louis Peter Castellanos , Yuyin Chen , Marc Poirier , Ingrid Mergelsberg
- Applicant: OPKO Health, Inc.
- Applicant Address: US FL Miami
- Assignee: OPKO Health, Inc.
- Current Assignee: OPKO Health, Inc.
- Current Assignee Address: US FL Miami
- Agency: Choate, Hall & Stewart LLP
- Agent Brenda Herschbach Jarrell; Kristen C. Buteau
- Main IPC: C07D471/10
- IPC: C07D471/10 ; C07D207/267 ; C07C217/48 ; C07D498/04 ; C07D207/26
![Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds](/abs-image/US/2016/02/02/US09249144B2/abs.jpg.150x150.jpg)
Abstract:
This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.
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