Invention Grant
- Patent Title: Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production
- Patent Title (中): 可用作用于治疗病毒感染的药物组合物中的活性成分的膦酸核苷和用于其生产的中间体
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Application No.: US14317448Application Date: 2014-06-27
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Publication No.: US09249177B2Publication Date: 2016-02-02
- Inventor: Piet Herdewijn , Christophe Pannecouque , Tongfei Wu , Erik De Clercq
- Applicant: K.U. Leuven Research & Development
- Applicant Address: BE Leuven
- Assignee: K.U. Leuven Research & Development
- Current Assignee: K.U. Leuven Research & Development
- Current Assignee Address: BE Leuven
- Agency: Clark & Elbing LLP
- Priority: GB0404891.4 20040304; GB0407712.9 20040405
- Main IPC: C07H19/20
- IPC: C07H19/20 ; C07H19/10 ; C07H19/048 ; C07H19/00 ; C07H19/06 ; C07H19/16 ; C07H1/00
Abstract:
The invention is directed to processes of preparing phosphonate nucleosides comprising a phosphonalkoxy-substituted five-membered, saturated or unsaturated, oxygen-containing ring coupled to a heterocyclic nucleobase such as a pyrimidine or purine base. These compounds can be described by the general formula (XIX)
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