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US09249178B2 Tricyclic nucleosides and oligomeric compounds prepared therefrom 有权
由其制备的三环核苷和寡聚化合物

Tricyclic nucleosides and oligomeric compounds prepared therefrom
Abstract:
The present invention provides novel tricyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound is expected to enhance one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions. In certain embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
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