Invention Grant
- Patent Title: Tricyclic nucleosides and oligomeric compounds prepared therefrom
- Patent Title (中): 由其制备的三环核苷和寡聚化合物
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Application No.: US14385050Application Date: 2013-03-15
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Publication No.: US09249178B2Publication Date: 2016-02-02
- Inventor: Christian Leumann , Branislav Dugovic , Jory Liétard
- Applicant: UNIVERSITÄT BERN
- Agency: Fanelli Haag PLLC
- Priority: EP12159716 20120315
- International Application: PCT/EP2013/055498 WO 20130315
- International Announcement: WO2013/135900 WO 20130919
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C07H21/00 ; C07H19/16 ; C07H19/04 ; C07H19/02 ; C07H19/06

Abstract:
The present invention provides novel tricyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound is expected to enhance one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions. In certain embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
Public/Granted literature
- US20150141637A1 TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM Public/Granted day:2015-05-21
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