Invention Grant
US09249179B2 Galactose cluster-pharmacokinetic modulator targeting moiety for siRNA
有权
用于siRNA的半乳糖簇 - 药代动力学调节剂靶向部分
- Patent Title: Galactose cluster-pharmacokinetic modulator targeting moiety for siRNA
- Patent Title (中): 用于siRNA的半乳糖簇 - 药代动力学调节剂靶向部分
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Application No.: US13327271Application Date: 2011-12-15
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Publication No.: US09249179B2Publication Date: 2016-02-02
- Inventor: Philipp Hadwiger , Torsten Hoffmann , Eric A. Kitas , Peter Mohr , Ingo Roehl , Linda Valis , David B. Rozema , David L. Lewis , Darren H. Wakefield
- Applicant: Philipp Hadwiger , Torsten Hoffmann , Eric A. Kitas , Peter Mohr , Ingo Roehl , Linda Valis , David B. Rozema , David L. Lewis , Darren H. Wakefield
- Applicant Address: US WI Madison
- Assignee: Arrowhead Madison Inc.
- Current Assignee: Arrowhead Madison Inc.
- Current Assignee Address: US WI Madison
- Agent Kirk Ekena
- Main IPC: A61K31/7088
- IPC: A61K31/7088 ; C07H21/02
Abstract:
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.
Public/Granted literature
- US20120157509A1 GALACTOSE CLUSTER-PHARMACOKINETIC MODULATOR TARGETING MOIETY FOR siRNA Public/Granted day:2012-06-21
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