Invention Grant
- Patent Title: Alpha-fetoprotein “ring and tail” peptides
- Patent Title (中): 甲胎蛋白“环和尾”肽
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Application No.: US13522882Application Date: 2011-01-18
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Publication No.: US09249189B2Publication Date: 2016-02-02
- Inventor: Thomas T. Andersen , Herbert I. Jacobson , James A. Bennett , Leroy Joseph , Alberto Bryan
- Applicant: Thomas T. Andersen , Herbert I. Jacobson , James A. Bennett , Leroy Joseph , Alberto Bryan
- Applicant Address: US NY Albany
- Assignee: ALBANY MEDICAL COLLEGE
- Current Assignee: ALBANY MEDICAL COLLEGE
- Current Assignee Address: US NY Albany
- Agency: Heslin Rothenberg Farley and Mesiti, PC
- Agent Kathy Smith Dias
- International Application: PCT/US2011/021560 WO 20110118
- International Announcement: WO2011/088462 WO 20110721
- Main IPC: C07K7/52
- IPC: C07K7/52 ; C07K7/64 ; A61K38/00 ; A61K38/12
Abstract:
The invention relates to compounds that are analogs of a cyclic peptide, cyclo[EKTOVNOGN] (SEQ ID NO: 13), AFPep, that has anti-estrotrophic activity. The analogs of the invention include peptides and peptidomimetics that inhibit estrogen receptor-dependent cell proliferation. The compounds of the invention are useful for treating cell proliferative disorders or physiological conditions characterized by undesirable or unwanted estrogen induced cell proliferation, including breast cancer.
Public/Granted literature
- US20130059794A1 ALPHA-FETOPROTEIN "RING AND TAIL" PEPTIDES Public/Granted day:2013-03-07
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