Invention Grant
- Patent Title: Neuron generation, regeneration and protection
- Patent Title (中): 神经元生成,再生和保护
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Application No.: US14312048Application Date: 2014-06-23
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Publication No.: US09249194B2Publication Date: 2016-02-02
- Inventor: Christophe Prehaud , Monique Lafon , Matthias Johannes Schnell
- Applicant: INSTITUT PASTEUR , THOMAS JEFFERSON UNIVERSITY
- Applicant Address: FR Paris US PA Philadelphia
- Assignee: INSTITUT PASTEUR,THOMAS JEFFERSON UNIVERSITY
- Current Assignee: INSTITUT PASTEUR,THOMAS JEFFERSON UNIVERSITY
- Current Assignee Address: FR Paris US PA Philadelphia
- Priority: EP09290257 20090407
- Main IPC: A61K38/16
- IPC: A61K38/16 ; C07K14/005 ; A61K35/766 ; A61K35/13 ; A61K38/00

Abstract:
The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth promoting effect. The invention further demonstrates that this neurite outgrowth promoting effect is due to the cytoplasmic tail of the non-apoptotic rabies virus G proteins, more particularly to their PDZ-BS, which shows a single-point mutation compared to the one of apoptotic rabies virus G proteins. The invention provides methods for inducing and/or stimulating neurite outgrowth, which are useful in inducing neuron differentiation, for example for the treatment of a neoplasm of the nervous system, as well as in regenerating impaired neurons, for example for the treatment of a neurodegenerative disease, disorder or condition or in the treatment of a microbial infection, or in protecting neurons from neurotoxic agents or oxidative stress.
Public/Granted literature
- US20140341858A1 NEURON GENERATION, REGENERATION AND PROTECTION Public/Granted day:2014-11-20
Information query
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