Invention Grant
- Patent Title: Bispecific EGFRvIII x CD3 antibody engaging molecules
- Patent Title (中): 双特异性EGFRvIII x CD3抗体接合分子
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Application No.: US13296809Application Date: 2011-11-15
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Publication No.: US09249217B2Publication Date: 2016-02-02
- Inventor: Darell D. Bigner , Chien-Tsun Kuan , John H. Sampson , Mingqing Cai , Bryan D. Choi , Ira H. Pastan
- Applicant: Darell D. Bigner , Chien-Tsun Kuan , John H. Sampson , Mingqing Cai , Bryan D. Choi , Ira H. Pastan
- Applicant Address: US MD Rockville US NC Durham
- Assignee: Secretary, DHHS,Duke University
- Current Assignee: Secretary, DHHS,Duke University
- Current Assignee Address: US MD Rockville US NC Durham
- Agency: Banner & Witcoff, LTD.
- Main IPC: C12N15/10
- IPC: C12N15/10 ; C07K16/28 ; C07K16/30 ; A61K39/00
Abstract:
We have constructed bispecific antibody engaging molecules which have one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The engaging molecules are highly cytotoxic and antigen-specific.
Public/Granted literature
- US20120189630A1 BISPECIFIC EGFRvIII ANTIBODY ENGAGING MOLECULES Public/Granted day:2012-07-26
Information query
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