Invention Grant
US09249412B2 Simplified method for partial genetic and epigenetic reprogramming of cells using siRNA specific for a heterochromatin protein 1
有权
使用特异于异染色质蛋白的siRNA的细胞的部分遗传和表观遗传重编程的简化方法1
- Patent Title: Simplified method for partial genetic and epigenetic reprogramming of cells using siRNA specific for a heterochromatin protein 1
- Patent Title (中): 使用特异于异染色质蛋白的siRNA的细胞的部分遗传和表观遗传重编程的简化方法1
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Application No.: US13146158Application Date: 2010-01-07
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Publication No.: US09249412B2Publication Date: 2016-02-02
- Inventor: Fred Zacouto
- Applicant: Fred Zacouto
- Agency: Sughrue Mion, PLLC
- Priority: FR0950466 20090126; FR0957075 20091009
- International Application: PCT/FR2010/050022 WO 20100107
- International Announcement: WO2010/084275 WO 20100729
- Main IPC: C12N5/075
- IPC: C12N5/075 ; C12N15/113 ; C12N5/16 ; C12N15/63 ; C12N5/074 ; C12N15/11
Abstract:
A method of partial, rapid and direct genetic and epigenetic reprogramming of biological cells without returning to the embryonic state can partially reprogram a cell to be treated to specifically modify the biological age of said cell to be treated without causing functional de-differentiation of said cell to be treated, said cell to be treated always remaining as a specialized functional cell that is immunologically autologous to the donor tissue from which said cell to be treated is derived, and for which the phenotype is preserved and/or rejuvenated.
Public/Granted literature
- US20110287536A1 SIMPLIFIED METHOD FOR PARTIAL GENETIC AND EPIGENETIC REPROGRAMMING OF CELLS Public/Granted day:2011-11-24
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