Invention Grant
- Patent Title: Lentiviral vectors pseudotyped with mutant BaEV glycoproteins
- Patent Title (中): 用突变型BaEV糖蛋白假型分类的慢病毒载体
-
Application No.: US14346357Application Date: 2012-09-28
-
Publication No.: US09249426B2Publication Date: 2016-02-02
- Inventor: Anais Girard-Gagnepain , Els Verhoeyen , Dimitri Lavillette , Francois-Loic Cosset
- Applicant: Anais Girard-Gagnepain , Els Verhoeyen , Dimitri Lavillette , Francois-Loic Cosset
- Applicant Address: FR Paris FR Lyons
- Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM),Ecole Normale Superieur de Lyon
- Current Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM),Ecole Normale Superieur de Lyon
- Current Assignee Address: FR Paris FR Lyons
- Agency: Whitham Curtis Christofferson & Cook, PC
- Priority: EP11306247 20110929
- International Application: PCT/EP2012/069230 WO 20120928
- International Announcement: WO2013/045639 WO 20130404
- Main IPC: A01N63/00
- IPC: A01N63/00 ; C12N15/86 ; C07K14/005 ; A61K48/00
Abstract:
The present invention concerns a pseudotyped viral vector particle for transferring biological material into cells, wherein said vector particle comprises at least:—a chimeric envelope glycoprotein which comprises or consists in a fusion of the transmembrane and extracellular domain of a baboon endogenous retrovirus (BaEV) envelope glycoprotein and the cytoplasmic tail domain of a murine leukemia virus (MLV) envelope glycoprotein; or—a modified BaEV envelope glycoprotein wherein the cytoplasmic tail domain is devoid of the fusion inhibitory R peptide.
Public/Granted literature
- US20140235700A1 LENTIVIRAL VECTORS PSEUDOTYPED WITH MUTANT BaEV GLYCOPROTEINS Public/Granted day:2014-08-21
Information query
