Invention Grant
- Patent Title: Recombinant HCMV and RHCMV vectors and uses thereof
- Patent Title (中): 重组HCMV和RHCMV载体及其用途
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Application No.: US13694280Application Date: 2012-11-14
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Publication No.: US09249427B2Publication Date: 2016-02-02
- Inventor: Louis Picker , Jay A. Nelson , Klaus Frueh , Michael A. Jarvis , Scott G. Hansen
- Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
- Applicant Address: US OR Portland
- Assignee: Oregon Health & Science University
- Current Assignee: Oregon Health & Science University
- Current Assignee Address: US OR Portland
- Agency: Schwabe Williamson & Wyatt
- Main IPC: A61K39/21
- IPC: A61K39/21 ; C12N15/63 ; A61P31/18 ; C12N15/38 ; C12N15/48 ; C12N15/49 ; C07K14/045 ; C07K14/16 ; C12N15/869 ; A61K39/12 ; C12N15/86 ; A61K39/00 ; A61K39/08 ; A61K39/13 ; A61K39/145 ; A61K39/275
Abstract:
The present invention relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.
Public/Granted literature
- US20130136768A1 Recombinant HCMV and RHCMV vectors and uses thereof Public/Granted day:2013-05-30
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