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US09249430B2 Recombinant microorganisms having phosphoketolase activity and diminished phosphofructokinase activity and/or glucose-6 phosphate dehydrogenase activity 有权
具有磷酸酮糖苷酶活性和降低的磷酸果糖激酶活性和/或葡萄糖-6-磷酸脱氢酶活性的重组微生物

  • Patent Title: Recombinant microorganisms having phosphoketolase activity and diminished phosphofructokinase activity and/or glucose-6 phosphate dehydrogenase activity
  • Patent Title (中): 具有磷酸酮糖苷酶活性和降低的磷酸果糖激酶活性和/或葡萄糖-6-磷酸脱氢酶活性的重组微生物
  • Application No.: US14232011
    Application Date: 2012-07-12
  • Publication No.: US09249430B2
    Publication Date: 2016-02-02
  • Inventor: Philippe Marliere
  • Applicant: Philippe Marliere
  • Applicant Address: LU Luxembourg
  • Assignee: Scientist of Fortune, S.A.
  • Current Assignee: Scientist of Fortune, S.A.
  • Current Assignee Address: LU Luxembourg
  • Agency: InHouse Patent Counsel, LLC
  • Agent Michele M. Wales
  • Priority: EP111735635 20110712
  • International Application: PCT/EP2012/063685 WO 20120712
  • International Announcement: WO2013/007786 WO 20130117
  • Main IPC: C12N15/63
  • IPC: C12N15/63 C12N9/16 C12N9/88 C12P7/28 C12P19/32 C12P5/02
Recombinant microorganisms having phosphoketolase activity and diminished phosphofructokinase activity and/or glucose-6 phosphate dehydrogenase activity
Abstract:
Described are recombinant microorganisms characterized by having phosphoketolase activity, having a diminished or inactivated Embden-Meyerhof-Parnas pathway (EMPP) by inactivation of the gene(s) encoding phosphofructokinase or by reducing phosphofructokinase activity as compared to a non-modified microorganism and having a diminished or inactivated oxidative branch of the pentose phosphate pathway (PPP) by inactivation of the gene(s) encoding glucose-6-phosphate dehydrogenase or by reducing glucose-6-phosphate dehydrogenase activity as compared to a non-modified microorganism. These microorganisms can be used for the production of useful metabolites such as acetone, isobutene or propene.
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