Invention Grant
US09249430B2 Recombinant microorganisms having phosphoketolase activity and diminished phosphofructokinase activity and/or glucose-6 phosphate dehydrogenase activity
有权
具有磷酸酮糖苷酶活性和降低的磷酸果糖激酶活性和/或葡萄糖-6-磷酸脱氢酶活性的重组微生物
- Patent Title: Recombinant microorganisms having phosphoketolase activity and diminished phosphofructokinase activity and/or glucose-6 phosphate dehydrogenase activity
- Patent Title (中): 具有磷酸酮糖苷酶活性和降低的磷酸果糖激酶活性和/或葡萄糖-6-磷酸脱氢酶活性的重组微生物
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Application No.: US14232011Application Date: 2012-07-12
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Publication No.: US09249430B2Publication Date: 2016-02-02
- Inventor: Philippe Marliere
- Applicant: Philippe Marliere
- Applicant Address: LU Luxembourg
- Assignee: Scientist of Fortune, S.A.
- Current Assignee: Scientist of Fortune, S.A.
- Current Assignee Address: LU Luxembourg
- Agency: InHouse Patent Counsel, LLC
- Agent Michele M. Wales
- Priority: EP111735635 20110712
- International Application: PCT/EP2012/063685 WO 20120712
- International Announcement: WO2013/007786 WO 20130117
- Main IPC: C12N15/63
- IPC: C12N15/63 ; C12N9/16 ; C12N9/88 ; C12P7/28 ; C12P19/32 ; C12P5/02

Abstract:
Described are recombinant microorganisms characterized by having phosphoketolase activity, having a diminished or inactivated Embden-Meyerhof-Parnas pathway (EMPP) by inactivation of the gene(s) encoding phosphofructokinase or by reducing phosphofructokinase activity as compared to a non-modified microorganism and having a diminished or inactivated oxidative branch of the pentose phosphate pathway (PPP) by inactivation of the gene(s) encoding glucose-6-phosphate dehydrogenase or by reducing glucose-6-phosphate dehydrogenase activity as compared to a non-modified microorganism. These microorganisms can be used for the production of useful metabolites such as acetone, isobutene or propene.
Public/Granted literature
- US20140248669A1 RECOMBINANT MICROORGANISM FOR THE PRODUCTION OF USEFUL METABOLITES Public/Granted day:2014-09-04
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