Invention Grant
US09249451B2 Resonance energy transfer assay with cleavage sequence and spacer
有权
具有切割序列和间隔区的共振能量转移测定
- Patent Title: Resonance energy transfer assay with cleavage sequence and spacer
- Patent Title (中): 具有切割序列和间隔区的共振能量转移测定
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Application No.: US14631379Application Date: 2015-02-25
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Publication No.: US09249451B2Publication Date: 2016-02-02
- Inventor: Robert D. Fish , Min Dong
- Applicant: BIOMADISON, LLP
- Applicant Address: US CA Del Mar
- Assignee: BIOMADISON, INC.
- Current Assignee: BIOMADISON, INC.
- Current Assignee Address: US CA Del Mar
- Agency: Fish & Tsang, LLP
- Main IPC: G01N31/00
- IPC: G01N31/00 ; G01N33/53 ; C12Q1/37 ; G01N33/542 ; G01N33/94 ; C07K19/00 ; C07K14/47
Abstract:
A molecular construct comprises a donor label, an acceptor label, a linker peptide disposed between the donor and the acceptor, the linker having a cleavage site sequence, and a flexible peptide spacer between at least one of (a) the donor and the cleavage site sequence and (b) the acceptor and the cleavage site sequence. The cleavage site sequence is a protease cleavage site, and the flexible spacer peptide is positioned and dimensioned to facilitate an electronic hop between the donor and acceptor label.
Public/Granted literature
- US20150176051A1 Resonance Energy Transfer Assay with Cleavage Sequence and Spacer Public/Granted day:2015-06-25
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