Invention Grant
- Patent Title: Kits and methods for detecting methylated DNA
- Patent Title (中): 用于检测甲基化DNA的试剂盒和方法
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Application No.: US11720300Application Date: 2005-11-28
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Publication No.: US09249464B2Publication Date: 2016-02-02
- Inventor: Michael Rehli
- Applicant: Michael Rehli
- Applicant Address: US CA San Diego
- Assignee: SEQUENOM, INC.
- Current Assignee: SEQUENOM, INC.
- Current Assignee Address: US CA San Diego
- Agency: Grant IP, Inc.
- Priority: EP04028268 20041129
- International Application: PCT/EP2005/012705 WO 20051128
- International Announcement: WO2006/056478 WO 20060601
- Main IPC: C12P19/34
- IPC: C12P19/34 ; C12Q1/68

Abstract:
The present invention relates to an in vitro method for detecting methylated DNA comprising (a) coating a container with a polypeptide capable of binding methylated DNA; (b) contacting said polypeptide with a sample comprising methylated and/or unmethylated DNA; and (c) detecting the binding of said polypeptide to methylated DNA. In a preferred embodiment, said method further comprises step (d) analyzing the detected methylated DNA by sequencing. Another aspect of the present invention is a kit for detecting methylated DNA according to the methods of the invention comprising (a) a polypeptide capable of binding methylated DNA; (b) a container which can be coated with said polypeptide; (c) means for coating said container; and (d) means for detecting methylated DNA.
Public/Granted literature
- US20090130659A1 KITS AND METHODS FOR DETECTING METHYLATED DNA Public/Granted day:2009-05-21
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