Invention Grant
US09249464B2 Kits and methods for detecting methylated DNA 有权
用于检测甲基化DNA的试剂盒和方法

  • Patent Title: Kits and methods for detecting methylated DNA
  • Patent Title (中): 用于检测甲基化DNA的试剂盒和方法
  • Application No.: US11720300
    Application Date: 2005-11-28
  • Publication No.: US09249464B2
    Publication Date: 2016-02-02
  • Inventor: Michael Rehli
  • Applicant: Michael Rehli
  • Applicant Address: US CA San Diego
  • Assignee: SEQUENOM, INC.
  • Current Assignee: SEQUENOM, INC.
  • Current Assignee Address: US CA San Diego
  • Agency: Grant IP, Inc.
  • Priority: EP04028268 20041129
  • International Application: PCT/EP2005/012705 WO 20051128
  • International Announcement: WO2006/056478 WO 20060601
  • Main IPC: C12P19/34
  • IPC: C12P19/34 C12Q1/68
Kits and methods for detecting methylated DNA
Abstract:
The present invention relates to an in vitro method for detecting methylated DNA comprising (a) coating a container with a polypeptide capable of binding methylated DNA; (b) contacting said polypeptide with a sample comprising methylated and/or unmethylated DNA; and (c) detecting the binding of said polypeptide to methylated DNA. In a preferred embodiment, said method further comprises step (d) analyzing the detected methylated DNA by sequencing. Another aspect of the present invention is a kit for detecting methylated DNA according to the methods of the invention comprising (a) a polypeptide capable of binding methylated DNA; (b) a container which can be coated with said polypeptide; (c) means for coating said container; and (d) means for detecting methylated DNA.
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