A ram assembly of a blowout prevent (BOP) includes a ram shuttle, a ram wedge and a ram seat. The ram shuttle and the ram wedge are slidably positionable in a ram channel of a BOP housing between a retracted and extended position. The ram shuttle has a wedge cavity extending therethrough and an inclined surface thereon. The ram wedge has a tubular cavity therethrough for receiving the tubular. The ram wedge has a corresponding inclined surface engageable with the inclined surface of the ram shuttle, and wedges between the ram shuttle and the housing whereby a force is generated therebetween. The ram seat is positionable in the housing about the passage, and is engageable with the ram wedge and the housing when the ram shuttle and the ram wedge are moved to the extended position whereby a seal is formed therebetween.