Invention Grant
- Patent Title: Controlled translocation of macromolecules employing a funnel nanopore structure and a gel
- Patent Title (中): 使用漏斗状纳米孔结构和凝胶控制大分子的易位
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Application No.: US14022718Application Date: 2013-09-10
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Publication No.: US09250207B2Publication Date: 2016-02-02
- Inventor: George F. Walker
- Applicant: International Business Machines Corporation
- Applicant Address: US NY Armonk
- Assignee: International Business Machines Corporation
- Current Assignee: International Business Machines Corporation
- Current Assignee Address: US NY Armonk
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Agent Louis J. Percello, Esq.
- Main IPC: G01N27/447
- IPC: G01N27/447

Abstract:
A system of controlled translocation of macromolecules by gel electrophesis employs a funnel nanopore structure. A graphene portion is attached to a porous material layer including funnel-shaped pores such that the graphene portion blocks the side of the porous material layer having openings for smaller pores. A pair of electrical contacts is formed on the graphene portion. A dielectric material layer may be deposited to hold the graphene portion in place. A nanoscale hole is formed through the dielectric material layer and the graphene portion to provide a smallest opening in a funnel nanopore structure. The funnel nanopore structure is placed within a capsule configured for gel electrophoresis. A linear chain of molecules can pass through a funnel-shaped pore and the nanoscale hole during the gel electrophoresis. A graphene nanopore detector allows measurement of blockage current for sufficient resolution of base pairs in DNA's.
Public/Granted literature
- US20140299473A1 CONTROLLED TRANSLOCATION OF MACROMOLECULES EMPLOYING A FUNNEL NANOPORE STRUCTURE AND A GEL Public/Granted day:2014-10-09
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