Invention Grant
US09250231B2 Method for selecting mevalonate synthesis modulators using cells derived from human pluripotent cells
有权
使用源自人多能细胞的细胞选择甲羟戊酸合成调节剂的方法
- Patent Title: Method for selecting mevalonate synthesis modulators using cells derived from human pluripotent cells
- Patent Title (中): 使用源自人多能细胞的细胞选择甲羟戊酸合成调节剂的方法
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Application No.: US14278610Application Date: 2014-05-15
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Publication No.: US09250231B2Publication Date: 2016-02-02
- Inventor: Christian Pinset
- Applicant: Centre d'Etude des Cellules Souches
- Applicant Address: FR Evry
- Assignee: Centre D'Etude Des Cellules Souches
- Current Assignee: Centre D'Etude Des Cellules Souches
- Current Assignee Address: FR Evry
- Agency: Alston & Bird LLP
- Priority: EP10166631 20100621
- Main IPC: C12Q1/02
- IPC: C12Q1/02 ; G01N33/50 ; C12N5/0775
Abstract:
The invention provides a method for selecting pharmaceutical compounds that enhance inhibition of mevalonate synthesis in which mesodermal stem cells (MSC type) that are derived from human pluripotent cells or from induced stem cell are contacted with pharmaceutical compounds to be tested in the presence of an inhibitor of mevalonate synthesis. Pharmaceutical compounds are then identified which enhance cell toxicity in the presence of the inhibitors.
Public/Granted literature
- US20140248653A1 Method For Selecting Mevalonate Synthesis Modulators Using Cells Derived From Human Pluripotent Cells Public/Granted day:2014-09-04
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