Invention Grant
- Patent Title: Compositions and methods for detecting microbial infections
- Patent Title (中): 用于检测微生物感染的组合物和方法
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Application No.: US14175001Application Date: 2014-02-07
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Publication No.: US09250239B2Publication Date: 2016-02-02
- Inventor: Nisha J. Garg
- Applicant: Nisha J. Garg
- Applicant Address: US TX Austin
- Assignee: The Board of Regents of the University of Texas System
- Current Assignee: The Board of Regents of the University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Norton Rose Fulbright US LLP
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/569 ; A61K39/005 ; A61K39/00

Abstract:
Provided herein are vaccine compositions for control of Trypanosoma cruzi infection and Chagas disease. The compositions comprise plasmids encoding o GPI-anchored genes ASP-2, TcG-1, TcG2 and TcG4 from Trypanosoma cruzi; plasmids encoding cytokines IL12 and GM-CSF; and plasmids encoding a gene expression system. Certain vaccine compositions comprise recombinant proteins, selected from TcG-1, TcG2 and TcG4 from Trypanosoma cruzi. In another vaccination strategy, the recombinant proteins are replaced by lysates comprising Trypanosoma rangeli cells. Further provided herein are diagnosis compositions comprising 1) recombinant proteins, selected from TcG-1, TcG2 and TcG4 from Trypanosoma cruzi; 2) antibodies that specifically binds the TcG-1, TcG2 and TcG4 proteins; 3) sense and antisense polynucleotide sequences that encode the TcG-1, TcG2 and TcG4 proteins. Said compositions can be used in diagnosing and/or evaluating efficacy of treatments against Trypanosoma cruzi infection. A diagnosis kit, and methods of diagnosing and/or treating Trypanosoma cruzi infection are also provided.
Public/Granted literature
- US20140220603A1 COMPOSITIONS AND METHODS FOR DETECTING MICROBIAL INFECTIONS Public/Granted day:2014-08-07
Information query
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