Various embodiments of systems and methods for performing backup operation in In-memory database systems are described herein. The method includes receiving a request to create a backup of a data set from a main memory of the system. In response to the request, the data set is configured as read-only and a data structure having meta-data information identifying the blocks of data in the main memory that form the data set is invoked. A snapshot of the data structure is created and the data set is enabled for manipulation. Further, the method involves receiving a request to modify a block of data and copying the requested data block to a free memory block in the main memory. The data structure is updated by replacing the meta-data identifying the requested original data block with meta-data identifying the free memory block which holds a copy of the requested data block.