Described are embodiments of methods, apparatuses, and systems for multi-protocol tunneling across a multi-protocol I/O interconnect of computer apparatus. A method for configuring a multi-protocol I/O interconnect may include identifying a plurality of switches of a switching fabric of a multi-protocol I/O interconnect, and configuring a path from a port of a first switch of the plurality of switches to a port of a second switch of the plurality of switches. Packets of a first protocol and packets of a second protocol, different from the first protocol, may be simultaneously routed over the path. Other embodiments may be described and claimed.