Embodiments of system, device, and method configurations for managing inter-radio access technology (inter-RAT) mobility of handovers between a UMTS Terrestrial Radio Access Network (UTRAN) or GSM EDGE Radio Access Network (GERAN) and an evolved UMTS Terrestrial Radio Access Network (E-UTRAN) to avoid scenarios of in-device coexistence (IDC) interference are disclosed herein. In one example, the existence and types of IDC interference with an E-UTRAN Long Term Evolution (LTE)/Long Term Evolution-Advanced (LTE-A) network are determined and communicated to the UTRAN/GERAN in an IDC indication signal. The IDC indication signal may communicate the existence and type of IDC interference occurring at user equipment, such as between licensed LTE/LTE-A and unlicensed industrial scientific medical (ISM) radio frequency bands. Accordingly, the UTRAN/GERAN may use information provided from the IDC indication signal to prevent a handover to the E-UTRAN that would result in IDC interference.