A method for operating a self-propelled harvesting machine with a plurality of working assemblies for processing picked-up crop, includes controlling the working assemblies using a control device assigned to the harvesting machine. At least one working assembly of the working assemblies is controlled by an input mechanism operatively connected to the control device and having a specific first function (F1) in the harvesting mode. A second function (F2), which deviates from the first function (F1) is assigned to the input mechanism by the control device depending on an operating state change. The second function (F2) is specific for the working assembly in an operating state that deviates from the harvesting mode.