Methods and systems for using feedback to minimize and treat cardiac fibrillation in a patient, includes generating a map of one or more measurements indicative of a number and distribution of electrical circuit cores for a duration across a cardiac tissue substrate in the patient's heart in response to electrical activity, defining an optimal placement of at least one ablation lesion in the cardiac tissue substrate; applying ablation lesion therapy based on the optimal placement; determining whether the ablation lesion therapy minimized or treated cardiac fibrillation; if therapy is determined to have minimized or treated cardiac fibrillation, assessing fibrillogenicity of the cardiac tissue substrate to determine whether fibrillogenicity is below a predetermined threshold; and if therapy is determined to have not minimized or treated cardiac fibrillation, repeating the steps of generating, defining, applying, and determining until ablation lesion therapy minimizes or treats cardiac fibrillation.