A surgical access device includes an elongate cannula having a side wall at the proximal end that is coaxial with and movable relative to a seal-housing. A seal assembly that includes at least one seal is disposed within the seal-housing. An inflation port is formed in on the seal housing and configured to align with an opening in the side wall at the proximal end of the cannula. The seal housing is movable relative to the side wall between an open and closed configuration. In an open configuration, the inflation port is aligned with the opening in the side wall permitting fluid to flow across the cannula side wall. In a closed configuration, the inflation fort is offset from the opening in the side wall preventing fluid flow across the cannula side wall. In one variation, a resilient retention member is disposed inside the seal housing to bias the seal.