For lightening or eradicating pigments in human skin, a first conditioning laser optical energy having first optical parameters selected to obtain an ablative effect on the epidermal layer of human skin is provided. A target area of the human skin is conditioned by directing the first conditioning laser optical energy onto the target area and forming in an epidermal layer of the target area discrete pressure and gas release ducts across the target area. A second treatment laser optical energy is provided that has second optical parameters selected to obtain a lightening or eradicating effect on the pigments located within the human skin and to substantially avoid damaging the epidermal layer of the human skin. The second treatment laser optical energy is directed onto the target area subsequent to conditioning, and the pigments within the human skin are lightenmed or eradicated by the second treatment laser optical energy.