Invention Grant
- Patent Title: Amphiphilic block copolymers for nucleic acid delivery
- Patent Title (中): 用于核酸递送的两亲性嵌段共聚物
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Application No.: US12991321Application Date: 2009-05-14
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Publication No.: US09254258B2Publication Date: 2016-02-09
- Inventor: Andrew Lennard Lewis , Giuseppe Battaglia , Irene Canton , Peter William Stratford
- Applicant: Andrew Lennard Lewis , Giuseppe Battaglia , Irene Canton , Peter William Stratford
- Applicant Address: GB Farnham Surrey
- Assignee: BIOCOMPATIBLES UK LIMITED
- Current Assignee: BIOCOMPATIBLES UK LIMITED
- Current Assignee Address: GB Farnham Surrey
- Agency: Sughrue Mion, PLLC
- Priority: EP08156272 20080515
- International Application: PCT/EP2009/055864 WO 20090514
- International Announcement: WO2009/138472 WO 20091119
- Main IPC: A61K9/51
- IPC: A61K9/51 ; A61K9/00 ; C12N5/071 ; A61K31/7105 ; B82Y5/00 ; A61K9/127 ; A61K48/00 ; C12N15/11
Abstract:
The present invention provides a composition comprising vesicles and encapsulated within the vesicles, nucleic acid comprising less than 1000 nucleotides, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block.Methods of forming vesicles and methods of delivering nucleic acid, in particular, iRNA into cells, are also provided.
Public/Granted literature
- US20110151013A1 AMPHIPHILIC BLOCK COPOLYMERS FOR NUCLEIC ACID DELIVERY Public/Granted day:2011-06-23
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