Invention Grant
- Patent Title: Inhibiting surface enhanced crystallization of amorphous pharmaceuticals with ultrathin coatings
- Patent Title (中): 用超薄涂层抑制无定形药物的表面增强结晶
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Application No.: US12053244Application Date: 2008-03-21
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Publication No.: US09254266B2Publication Date: 2016-02-09
- Inventor: Lian Yu , Melgardt M. De Villiers , Tian Wu
- Applicant: Lian Yu , Melgardt M. De Villiers , Tian Wu
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Bell & Manning, LLC
- Main IPC: A61K31/4422
- IPC: A61K31/4422 ; A61K31/405 ; A61K9/00 ; A61K9/14
Abstract:
The present invention provides surface-stabilized amorphous pharmaceuticals comprising an amorphous pharmaceutical substrate coated with a biocompatible immobilizing material. Amorphous pharmaceutical substrates that are prone to surface enhanced crystallization benefit from the present coatings. The coated amorphous pharmaceuticals of the present invention maintain their amorphous state and, therefore, their solubility over extended periods of time, relative to uncoated pharmaceuticals.
Public/Granted literature
- US20080233157A1 INHIBITING SURFACE ENHANCED CRYSTALLIZATION OF AMORPHOUS PHARMACEUTICALS WITH ULTRATHIN COATINGS Public/Granted day:2008-09-25
Information query
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