Invention Grant
- Patent Title: Elastin protective polyphenolics and methods of using the same
-
Application No.: US14150742Application Date: 2014-01-08
-
Publication No.: US09254300B2Publication Date: 2016-02-09
- Inventor: Thomas Mitts , Felipe Jimenez , Aleksander Hinek
- Applicant: HUMAN MATRIX SCIENCES, LLC , THE HOSPITAL FOR SICK CHILDREN
- Applicant Address: US CA Visalia CA Toronto, ON
- Assignee: Human Matrix Sciences, LLC,The Hospital for Sick Children
- Current Assignee: Human Matrix Sciences, LLC,The Hospital for Sick Children
- Current Assignee Address: US CA Visalia CA Toronto, ON
- Agency: Pepper Hamilton LLP
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K31/05 ; A61P9/00 ; A61K31/7028 ; A61K8/02 ; A61K8/60 ; A61Q19/08 ; A61K31/352

Abstract:
Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.
Public/Granted literature
- US20140155335A1 ELASTIN PROTECTIVE POLYPHENOLICS AND METHODS OF USING THE SAME Public/Granted day:2014-06-05
Information query