Invention Grant
- Patent Title: Adenoviral vector-based malaria vaccines
- Patent Title (中): 基于腺病毒载体的疟疾疫苗
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Application No.: US13890422Application Date: 2013-05-09
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Publication No.: US09254316B2Publication Date: 2016-02-09
- Inventor: Joseph T. Bruder , C. Richter King , Thomas Richie , Keith Limbach , Denise Louise Doolan
- Applicant: Joseph T. Bruder , C. Richter King , Thomas Richie , Keith Limbach , Denise Louise Doolan
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Navy
- Current Assignee: The United States of America as represented by the Secretary of the Navy
- Current Assignee Address: US DC Washington
- Agent Ning Yang; Albert M. Churilla; Diane Tso
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/015 ; C07H21/04 ; C12N7/00
Abstract:
The invention provides a method of inducing an immune response against malaria in a mammal. The method comprises intramuscularly administering to a mammal a composition comprising a pharmaceutically acceptable carrier and either or both of (a) a first adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum circumsporozoite protein (CSP) operably linked to a human CMV promoter, and/or (b) a second adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum apical membrane antigen 1 (AMA-1) antigen operably linked to a human CMV promoter.
Public/Granted literature
- US20140335128A1 ADENOVIRAL VECTOR-BASED MALARIA VACCINES Public/Granted day:2014-11-13
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