Invention Grant
- Patent Title: Methods and compositions for delivery of active agents
- Patent Title (中): 用于递送活性剂的方法和组合物
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Application No.: US13697229Application Date: 2011-05-10
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Publication No.: US09254327B2Publication Date: 2016-02-09
- Inventor: Muthiah Manoharan , Kallanthottathil G. Rajeev
- Applicant: Muthiah Manoharan , Kallanthottathil G. Rajeev
- Applicant Address: US MA Cambridge
- Assignee: ALNYLAM PHARMACEUTICALS, INC.
- Current Assignee: ALNYLAM PHARMACEUTICALS, INC.
- Current Assignee Address: US MA Cambridge
- Agency: Blank Rome LLP
- International Application: PCT/US2011/035939 WO 20110510
- International Announcement: WO2011/143230 WO 20111117
- Main IPC: C12N15/11
- IPC: C12N15/11 ; A61K9/127 ; A61K31/13 ; A61K47/18 ; C12N15/88 ; A61K31/7088 ; C07C219/08 ; C07C229/12 ; C07C233/38 ; C07C237/06 ; C07C271/12 ; C07C271/64 ; C07C275/20
Abstract:
A lipid particle can include a cationic lipid. Synthesis of the cationic lipid can include a ylide-based reaction, such as a Wittig reaction or sulfur ylide reaction. In some cases, the synthesis can also include a Michael addition or a related addition reaction.
Public/Granted literature
- US20130129785A1 METHODS AND COMPOSITIONS FOR DELIVERY OF ACTIVE AGENTS Public/Granted day:2013-05-23
Information query
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