Methods of manufacture of pteroyl-amino acid-fluorescent dyes

Invention Grant

US09254341B2 Methods of manufacture of pteroyl-amino acid-fluorescent dyes 有权

Title translation: 蝶啶氨基酸荧光染料的制备方法

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Patent Title: Methods of manufacture of pteroyl-amino acid-fluorescent dyes
Patent Title (中): 蝶啶氨基酸荧光染料的制备方法
Application No.: US14046916

Application Date: 2013-10-04
Publication No.: US09254341B2

Publication Date: 2016-02-09
Inventor: Sumith A. Kularatne , Pravin Gagare , Mohammad Noshi
Applicant: On Target Laboratories, LLC
Agency: McAndrews, Held & Malloy Ltd
Main IPC: C07D475/00
IPC: C07D475/00 ; A61K49/00 ; G01N33/569 ; G01N33/566 ; G01N33/50

Methods of manufacture of pteroyl-amino acid-fluorescent dyes

Abstract:

The present invention discloses a process for preparing a compound having the formula Including Reacting a compound of the formula 1: with a compound of the formula: in the presence of a polar solvent and trifluoroacetic acid to provide a compound of the formula: or a racemic mixture thereof; and further reacting the compound of the formula: or a racemic mixture thereof; with sodium hydroxide and a compound of the formula: wherein R1 and R2 are as defined above.

Abstract(Chinese):

本发明公开了一种制备具有下式的化合物的方法：包括使式1化合物与下式化合物在极性溶剂和三氟乙酸的存在下反应，得到下式的化合物或外消旋的混合物并进一步使下式化合物或其外消旋混合物反应; 与氢氧化钠和下式的化合物反应：其中R1和R2如上定义。

Public/Granted literature

US20140275533A1 Methods of Manufacture and Synthesis of Amino Acid Linking Groups Conjugated To Compounds Used For Targeted Imaging of Tumors Public/Granted day:2014-09-18

Information query

Espacenet

IPC分类:

C	化学；冶金
C07	有机化学
C07D	杂环化合物（高分子化合物入C08）
C07D475/00	含蝶啶环系的杂环化合物