A method for operating a safety system of a motor vehicle includes the steps of determining a target trajectory of the motor vehicle to be realized with the safety system after an unavoidable collision, wherein the target trajectory is assigned to a target position of the motor vehicle, which target position is safe with regard to secondary collisions, and performing at least one autonomous and/or supporting driving intervention in the form of at least one of a longitudinally guiding intervention and a transverse guiding intervention after the collision for realizing the target trajectory.