A wire guide for use in a welding wire feeder is provided. The wire guide includes two guide surfaces spaced from one another to define an opening through which welding wire is directed from a spool to a wire drive assembly of the wire feeder. The wire guide may also include a side flange extending from an outboard position of the wire guide to maintain the wire within a desired region of the wire drive assembly, such as a space formed by grooves along rollers of the wire drive assembly. The side flange may be formed integrally with an outboard guide surface of the wire guide. The guide surfaces and the side flange may be formed integrally into a one-piece wire guide structure.