Invention Grant
US09255062B2 Fatty acid derivatives for oral administration endowed with high palatability
有权
用于口服给药的脂肪酸衍生物具有高适口性
- Patent Title: Fatty acid derivatives for oral administration endowed with high palatability
- Patent Title (中): 用于口服给药的脂肪酸衍生物具有高适口性
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Application No.: US12988556Application Date: 2009-04-21
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Publication No.: US09255062B2Publication Date: 2016-02-09
- Inventor: Roberto Berni Canani , Antonio Calignano , Orazio Mazzoni , Anna Coruzzo
- Applicant: Roberto Berni Canani , Antonio Calignano , Orazio Mazzoni , Orietta Mazzoni , Anna Coruzzo
- Agency: Greer Burns & Crain Ltd.
- Agent Gregory P. Einhorn
- Priority: ITRM2008A0214 20080421
- International Application: PCT/IT2009/000179 WO 20090421
- International Announcement: WO2009/130735 WO 20091029
- Main IPC: A61K31/40
- IPC: A61K31/40 ; A61K31/44 ; A61K31/165 ; C07D213/127 ; C07D207/04 ; C07C15/04 ; C07C231/02 ; C07C233/31 ; C07C233/91

Abstract:
The invention relates to novel derivatives of short-chain fatty acids, in particular derivatives of butyric acid, useful for all the known clinical applications of the latter, which show physicochemical characteristics suitable for an easy oral administration, being devoid of the unpleasant organoleptic properties that characterize butyrate. The new compounds are amide derivatives which can be synthesized by reaction of the corresponding fatty acid halide with a naturally occurring amino acid, phenylalanine or a suitable derivative thereof, and which are in a poorly hygroscopic, easily weighable form, stable to acids and alkalis and able to release the acid at the small and large bowel level in a constant manner over time. They do not have disagreeable odors and are practically tasteless, thus allowing the manufacture of preparations for oral administration also suitable for the therapy of chronic diseases and in the pediatric field.
Public/Granted literature
- US20110098319A1 FATTY ACID DERIVATIVES FOR ORAL ADMINISTRATION ENDOWED WITH HIGH PALATABILITY Public/Granted day:2011-04-28
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