Invention Grant
US09255068B2 Crystalline salts of (4S,4AS,5AR,12AS)-4-dimethylamino-3,10,12,12A-tetrahydroxy-7-[methoxy(methyl)amino)-methyl] acid amide and methods of using the same
有权
（4S，4AS，5AR，12AS）-4-二甲基氨基-3,10,12,12A-四羟基-7- [甲氧基（甲基）氨基） - 甲基]酰胺的结晶盐及其使用方法
![Crystalline salts of (4S,4AS,5AR,12AS)-4-dimethylamino-3,10,12,12A-tetrahydroxy-7-[methoxy(methyl)amino)-methyl] acid amide and methods of using the same](/docs/US/2016-02-09/US09255068B2/abs.jpg.600x600.jpg)
- Patent Title: Crystalline salts of (4S,4AS,5AR,12AS)-4-dimethylamino-3,10,12,12A-tetrahydroxy-7-[methoxy(methyl)amino)-methyl] acid amide and methods of using the same
- Patent Title (中): （4S，4AS，5AR，12AS）-4-二甲基氨基-3,10,12,12A-四羟基-7- [甲氧基（甲基）氨基） - 甲基]酰胺的结晶盐及其使用方法
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Application No.: US13471275Application Date: 2012-05-14
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Publication No.: US09255068B2Publication Date: 2016-02-09
- Inventor: Catherine Coulter , Sean M. Johnston , Farzaneh Seyedi
- Applicant: Catherine Coulter , Sean M. Johnston , Farzaneh Seyedi
- Applicant Address: US PR Fajardo US MA Boston
- Assignee: Warner Chilcott Company, LLC,Paratek Pharmaceuticals, Inc.
- Current Assignee: Warner Chilcott Company, LLC,Paratek Pharmaceuticals, Inc.
- Current Assignee Address: US PR Fajardo US MA Boston
- Agency: Fitzpatrick, Cella, Harper & Scinto
- Main IPC: A61K31/65
- IPC: A61K31/65 ; C07C237/26 ; C07C309/04 ; C07C239/20
![Crystalline salts of (4S,4AS,5AR,12AS)-4-dimethylamino-3,10,12,12A-tetrahydroxy-7-[methoxy(methyl)amino)-methyl] acid amide and methods of using the same](/abs-image/US/2016/02/09/US09255068B2/abs.jpg.150x150.jpg)
Abstract:
A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed having improved stability. In addition, a crystalline mono mesylate salt and crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide are also disclosed having improved stability. A pharmaceutical composition containing the crystalline salts and methods of treating inflammatory skin disorders and bacterial infections comprising administering the crystalline salts are also disclosed.
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