Invention Grant
US09255086B2 Control of hypoxia-inducible gene expression with oligooxopiperazine nonpeptidic helix mimetics
有权
用寡核苷酸非肽螺旋模拟物控制缺氧诱导型基因表达
- Patent Title: Control of hypoxia-inducible gene expression with oligooxopiperazine nonpeptidic helix mimetics
- Patent Title (中): 用寡核苷酸非肽螺旋模拟物控制缺氧诱导型基因表达
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Application No.: US14379450Application Date: 2013-02-19
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Publication No.: US09255086B2Publication Date: 2016-02-09
- Inventor: Paramjit S. Arora , Bogdan Olenyuk , Brooke Bullock Lau , Ivan Grishagin
- Applicant: Paramjit S. Arora , Bogdan Olenyuk , Brooke Bullock Lau , Ivan Grishagin
- Applicant Address: US NY New York US CA Los Angeles
- Assignee: New York University,University of Southern California
- Current Assignee: New York University,University of Southern California
- Current Assignee Address: US NY New York US CA Los Angeles
- Agency: LeClairRyan, a Professional Corporation
- International Application: PCT/US2013/026722 WO 20130219
- International Announcement: WO2013/123511 WO 20130822
- Main IPC: A61K31/496
- IPC: A61K31/496 ; C07D403/06 ; C07D403/14 ; C07D241/08 ; C12N15/63
Abstract:
The present invention relates to oligooxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF-1α. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
Public/Granted literature
- US20150018364A1 CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION WITH OLIGOOXOPIPERAZINE NONPEPTIDIC HELIX MIMETICS Public/Granted day:2015-01-15
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