Invention Grant
- Patent Title: Benzothiazole-based pyridinium compounds
- Patent Title (中): 基于苯并噻唑的吡啶鎓化合物
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Application No.: US13592386Application Date: 2012-08-23
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Publication No.: US09255091B2Publication Date: 2016-02-09
- Inventor: Charles M. Thompson , Sandip Bharate
- Applicant: Charles M. Thompson , Sandip Bharate
- Applicant Address: US MT Missoula
- Assignee: The University of Montana
- Current Assignee: The University of Montana
- Current Assignee Address: US MT Missoula
- Agency: Minerva, PLLC
- Agent Zachary Scott
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D213/72 ; C07D417/12
Abstract:
The compositions of the invention are novel benzothiazol-based pyridinium compounds with potent acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. Such compositions can be used, for example, to treat Alzheimer's Disease and other neurodegenerative disorders. The compounds of the invention can also be used to prevent or treat the neurotoxic effects of nerve agents (e.g., sarin gas or insecticides).
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