Invention Grant
- Patent Title: Dihydropyrimidinoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
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Application No.: US14148057Application Date: 2014-01-06
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Publication No.: US09255095B2Publication Date: 2016-02-09
- Inventor: Frédéric Gilbert Labéguère , Gregory John Robert Newsome , Luke Jonathan Alvey , Laurent Raymond Maurice Sanière , Stephen Robert Fletcher
- Applicant: Galapagos NV
- Applicant Address: BE Mechelen
- Assignee: GALAPAGOS NV
- Current Assignee: GALAPAGOS NV
- Current Assignee Address: BE Mechelen
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/519 ; A61K31/5377 ; A61K45/06

Abstract:
A compound according to Formula Ia: wherein L1, G, and R1 are as described herein. The present invention relates to novel compounds according to Formula I that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (IBD), rheumatoid arthritis, vasculitis, lung diseases (e.g. chronic obstructive pulmonary disease (COPD) and lung interstitial diseases (e.g. idiopathic pulmonary fibrosis (IPF))), neuroinflammatory conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.
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