Invention Grant
US09255103B2 Substituted pyrazolo[1,5-a]pyrazines as mGluR5 receptor modulators
有权
取代的吡唑并[1,5-a]吡嗪作为mGluR5受体调节剂
![Substituted pyrazolo[1,5-a]pyrazines as mGluR5 receptor modulators](/docs/US/2016-02-09/US09255103B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted pyrazolo[1,5-a]pyrazines as mGluR5 receptor modulators
- Patent Title (中): 取代的吡唑并[1,5-a]吡嗪作为mGluR5受体调节剂
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Application No.: US14228179Application Date: 2014-03-27
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Publication No.: US09255103B2Publication Date: 2016-02-09
- Inventor: P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , José Manuel Bartolomé-Nebreda , Susana Conde-Ceide , Gregor Macdonald , Han Min Tong , Carrie K. Jones
- Applicant: Vanderbilt University
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Ballard Spahr LLP
- Main IPC: C07D241/38
- IPC: C07D241/38 ; C07D487/04
![Substituted pyrazolo[1,5-a]pyrazines as mGluR5 receptor modulators](/abs-image/US/2016/02/09/US09255103B2/abs.jpg.150x150.jpg)
Abstract:
In one aspect, the invention relates to substituted pyrazolo[1,5-a]pyrazines analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Public/Granted literature
- US20140213593A1 BICYCLIC PYRAZOLE COMPOUNDS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS Public/Granted day:2014-07-31
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