Invention Grant
- Patent Title: Identification of surface-associated antigens for tumor diagnosis and therapy
- Patent Title (中): 鉴定肿瘤诊断和治疗的表面相关抗原
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Application No.: US12851980Application Date: 2010-08-06
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Publication No.: US09255131B2Publication Date: 2016-02-09
- Inventor: Özlem Türeci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schlüter , Dirk Usener , Philippe Thiel , Michael Koslowski
- Applicant: Özlem Türeci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schlüter , Dirk Usener , Philippe Thiel , Michael Koslowski
- Applicant Address: DE Mainz
- Assignee: GANYMED PHARMACEUTICALS AG
- Current Assignee: GANYMED PHARMACEUTICALS AG
- Current Assignee Address: DE Mainz
- Agency: Olson & Cepuritis, Ltd.
- Priority: DE102004023187 20040511
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/574 ; A61K51/10 ; A61K39/395 ; C07K14/47 ; C12Q1/68
Abstract:
An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.
Public/Granted literature
- US20110014628A1 Identification of Surface-Associated Antigens for Tumor Diagnosis and Therapy Public/Granted day:2011-01-20
Information query
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