Invention Grant
US09255151B2 Antibody specifically recognizing an epitope for switching to TH1 cell
有权
抗体特异性识别切换至TH1细胞的表位
- Patent Title: Antibody specifically recognizing an epitope for switching to TH1 cell
- Patent Title (中): 抗体特异性识别切换至TH1细胞的表位
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Application No.: US13861644Application Date: 2013-04-12
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Publication No.: US09255151B2Publication Date: 2016-02-09
- Inventor: Byoung Se Kwon
- Applicant: National Cancer Center
- Applicant Address: KR Goyang-Si, Gyeonggi-Do
- Assignee: National Cancer Center
- Current Assignee: National Cancer Center
- Current Assignee Address: KR Goyang-Si, Gyeonggi-Do
- Agency: Reinhart Boerner Van Deuren P.C.
- Priority: KR10-2012-0061791 20120608; KR10-2012-0088645 20120813
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C07K16/30 ; C07K7/06 ; C07K14/705 ; A61K39/00

Abstract:
The present invention relates to a novel epitope that converts T cell to type 1 helper T (TH1) cell. Specifically, the present invention relates to an epitope constituting the 56th to 65th amino acids (SEQ ID No. 2) of extracellular domain (ECD) of activation-inducible tumor necrosis factor receptor (AITR), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting T cell to TH1 cell and a method for converting T cell to TH1 cell, a pharmaceutical composition comprising the antibody for preventing or treating cancer, a method for treating cancer using the antibody, a composition comprising the antibody for enhancing immunity, and a method for enhancing immunity using the antibody.
Public/Granted literature
- US20140065152A1 NOVEL EPITOPE FOR SWITCHING TO TH1 CELL AND USE THEREOF Public/Granted day:2014-03-06
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