Invention Grant
US09255152B2 Antibody specifically recognizing an epitope for switching to Th2 cell and a method for converting T cell to type 2 helper T cell using the same
有权
特异性识别切换至Th2细胞的表位的抗体以及使用该T细胞将T细胞转化为2型辅助T细胞的方法
- Patent Title: Antibody specifically recognizing an epitope for switching to Th2 cell and a method for converting T cell to type 2 helper T cell using the same
- Patent Title (中): 特异性识别切换至Th2细胞的表位的抗体以及使用该T细胞将T细胞转化为2型辅助T细胞的方法
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Application No.: US13861675Application Date: 2013-04-12
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Publication No.: US09255152B2Publication Date: 2016-02-09
- Inventor: Byoung Se Kwon
- Applicant: National Cancer Center
- Applicant Address: KR Goyang-Si, Gyeonggi-Do
- Assignee: National Cancer Center
- Current Assignee: National Cancer Center
- Current Assignee Address: KR Goyang-Si, Gyeonggi-Do
- Agency: Reinhart Boerner Van Deuren P.C.
- Priority: KR10-2012-0061791 20120608; KR10-2012-0088647 20120813
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C07K16/30 ; C07K7/06 ; C07K14/705 ; A61K39/00
Abstract:
The present invention relates to a novel epitope to convert T cell to type 2 helper T (TH2) cell. Specifically, the present invention relates to an epitope constituting the 20th to 30th amino acids (SEQ ID No. 2) of extracellular domain (ECD) of activation-inducible tumor necrosis factor receptor (AITR), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting T cell to TH2 cell and a method of conversion, a pharmaceutical composition comprising the antibody for preventing or treating autoimmune disease, and a method for treating autoimmune disease using the antibody.
Public/Granted literature
- US20140072566A1 NOVEL EPITOPE FOR SWITCHING TO TH2 CELL AND USE THEREOF Public/Granted day:2014-03-13
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