Invention Grant
US09255156B2 Immunogenic synthetic glycoconjugate for the immunotherapy of melanoma
有权
免疫原性合成糖缀合物用于黑色素瘤的免疫治疗
- Patent Title: Immunogenic synthetic glycoconjugate for the immunotherapy of melanoma
- Patent Title (中): 免疫原性合成糖缀合物用于黑色素瘤的免疫治疗
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Application No.: US14183072Application Date: 2014-02-18
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Publication No.: US09255156B2Publication Date: 2016-02-09
- Inventor: Cristina Nativi , Lucio Toma , Barbara Richichi , Carlotta Lunghi
- Applicant: Cristina Nativi , Lucio Toma , Barbara Richichi , Carlotta Lunghi
- Applicant Address: IT Florence
- Assignee: Azienda Ospedaliero-Universitaria Careggi
- Current Assignee: Azienda Ospedaliero-Universitaria Careggi
- Current Assignee Address: IT Florence
- Agency: Ohlandt, Greeley, Ruggiero & Perle, L.L.P.
- Priority: ITFI2009A0230 20091104
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K16/44 ; A61K47/48

Abstract:
A specific antibody against a compound of formula (I) wherein X is O, NH, S, CH2; L is a linker that is a divalent spacer; A is an adjuvant or carrier that is an immunogenic molecule or an immunogenic particle; and wherein bonds between linker and saccharide moiety and between linker and carrier are of covalent type; wherein the linker L presents a chemical structure suitable to space the saccharide moiety and the carrier by 7-30 atoms when the adjuvant/carrier A is a biomacromolecule or by 19-30 atoms when the adjuvant/carrier A is a metallic nanoparticle; wherein the carrier/adjuvant A can be selected among a macromolecule, a macrocycle, a dendrimer, a liposome, a nanoparticle, an oligosaccharide featuring from two to five monosaccharidic units or cells like dendritic cells.
Public/Granted literature
- US20140161806A1 IMMUNOGENIC SYNTHETIC GLYCOCONJUGATE FOR THE IMMUNOTHERAPY OF MELANOMA Public/Granted day:2014-06-12
Information query
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